Decoding how Viagra tablets work.

Viagra tablets are Pfizer's formulation that has achieved enormous success in the treatment of men who are suffering from a type of impotence known as erectile dysfunction (ED). Said to be originally tested for the treatment of hypertension and angina pectoris by a group of pharmaceutical chemists working in Pfizer’s research laboratory, Viagra tablets were later found out to effectively produce erection among a group of impotent men. As a result of this discovery, Viagra tablets, after getting approval from the United States Food and Drug Administration in 1998, were subsequently marketed for the treatment of ED.

Eleven years after making its debut as the first oral erectile dysfunction treatment, Viagra tablets, despite the serendipity of their discovery, still remain a household name among a great number of men even in the face of numerous competitions.

For a majority of people who buy Viagra cheap, the issue of how well they know the drug, considering the ease of availability of the drug via the internet, is raised. Is it that they just buy Viagra online because it makes their penis achieve stronger erection? Is it that they just buy Viagra online with next day delivery because it helps them achieve their stud-like aim in bed? Whatever reasons put forward by these people for buying Viagra online with next day delivery, the drug is a complex one, and an understanding of its mechanism of action would help one to make a wise decision in using Viagra tablets.

Viagra tablets online contains sildenafil citrate active ingredient which is a known inhibitor of the phosphodiesterase type 5 enzyme. Through the inhibition of this enzyme, the pills exhibit their erectile function by relaxing the smooth muscles of the penis, thereby allowing for the flow of blood into the corpus cavernosum.

The flow of blood into the corpus cavernosum of the penis is possible because the NO binds to the receptors of the enzyme guanylate cyclase which makes the levels of cyclic guanosine monophosphate to be raised.

The key reaction that sets the other chain of reactions in motion is the inhibition of the PDE 5 enzyme, which is known to potently degrade cGMP. Sildenafil citrate, as a molecular structural analogue of cGMP, competitively binds to the PDE 5 enzyme, thereby inactivating the function of the enzyme in degrading cGMP.

Noteworthy of mention is that the raised levels of cGMP dilates the arteries which carries blood into the penis, and the accumulation of blood in the corpus cavernosum allows for the lengthening of the penis and its subsequent rigidity.

Viagra tablets, like a lot of other medications, could engender side effects, which could be severe if not taken with due consultations with a physician.

Known to synergistically interact with certain drugs to further produce complex reactions, Viagra tablets are contraindicated for these drugs. A good example of this is the contraindication of Viagra tablets with any form of nitrates, because of its ability to potentiate the hypotensive effect of nitrates.

Viagra tablets are advised to be taken four hours apart from alpha blockers – drugs used in the treatment of hypertension and benign prostatic hyperplasia – to boot. This is because these two set of drugs, when taken together, could massively lower the blood pressure.

Also, protease inhibitors can inhibit the metabolism of sildenafil, thereby raising the level of Viagra in the plasma and also the side effects of the drug.

Viagra tablets, because of its complex nature, have been shown not to be administered to patients suffering from some medical conditions, such as stroke.